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Improving patient outcomes with innovative diagnostics for
critical care: Actionable insights in real-time

Discover our Biomarker Solutions

The Biomarker Company

SphingoTec develops and markets innovative in vitro diagnostic (IVD) tests for novel and proprietary blood-based protein biomarkers for the diagnosis, outcome prediction, and monitoring of critical medical conditions, such as sepsis, acute heart failure, circulatory failure and acute kidney injury.

SphingoTec’s first-in-class biomarker tests are made available on its proprietary whole-blood point-of-care Nexus IB10 platform for convenient and rapid testing in near-patient and laboratory settings alongside a broad portfolio of standard-of-care test for critical care. For high-throughput testing in central laboratories, SphingoTec partners with global IVD players. 


SphingoTec is headquartered near Berlin, Germany while its wholly owned subsidiary Nexus Dx is based in San Diego, CA, USA.


All of SphingoTec's biomarkers are globally patent protected


Diagnostic assays for SphingoTec‘s biomarkers are available on its proprietary fully developed and commercialized  POC platform Nexus IB10


SphingoTec’s biomarkers are broadly validated and published in peer-reviewed journals


In collaboration with an international network of key opinion leaders, SphingoTec develops solutions for fighting mortality in critical care conditions


SphingoTec’s management builds on an extraordinary track-record in R&D and commercialization of novel diagnostic solutions

Innovative acute care biomarkers

Following a deep understanding of disease biology, SphingoTec developes novel biomarkers addressing diagnostically underserved critical care conditions such sepsis, acute heart failure, acute kidney injury, and cardiogenic shock

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Point-of-care testing with Nexus IB10 Analyzer

The CE-IVD marked Nexus IB10 platform is a fully automated rapid immunoassay point-of-care instrument. With a hands-on-time of less than 3 minutes the easy-to-use system provides in only 20 minutes test results for biomarkers that are crucial in the management of critical care patients.

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Acute Care Pathways


Diagnostic tools in Sepsis

Recent research has identified new molecules that are informative and help clinicians understand the etiology of the patient’s clinical symptoms, paving the way for personalized medicine in the field of sepsis.


Biomarkers and the management of COVID-19 patients 

The global COVID-19 pandemic has challenged health systems world-wide, with about 5% of patients requiring admission to intensive care units (ICU). Read more on the importance of novel and established biomarker assays in the management of critically ill COVID-19 patients.

Latest News

04. May 2021
German University Hospital Uniklinik RWTH Aachen and diagnostics company SphingoTec GmbH today announced that the endothelial function biomarker bio-ADM aids in the early risk stratification and management of patients suffering from severe COVID-19, in need for escalated intensive care treatment.
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23. March 2021
Diagnostics company SphingoTec GmbH (“SphingoTec”) announced today the first published data (1) on the biomarker DPP3 that can predict the evolution of organ function and survival in septic patients. Measured on top of routinely used standard parameters, such as Lactate and Procalcitonin, DPP3 is an early indicator of short-term outcomes and patient severity.
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18. February 2021
Diagnostics company SphingoTec GmbH announced today that two distinct processes are involved in the development of septic shock and that SphingoTec’s biomarkers for endothelial function (vascular integrity) and cardiovascular depression allow early identification of these underlying mechanisms requiring different interventions.
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Events & Expos

23. - 26. September 2021

09:31 - 09:33

Rostock, DE
The Forum Nephrologie is a scientific, educational, and networking meeting and part of the 13. Jahrestagung der DGfN. The main congress program will kick off with an opening ceremony on Thursday, followed by 2,5 days of scientific activity.
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31. August - 03. September 2021

11:00 - 20:00

Brussels, Belgium
This year is the 40th edition of the ISICEM congress in Brussels and we are delighted to once again be exhibiting.
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28. February - 05. March 2021

09:35 - 09:35

The CRRT conference provides a comprehensive review of advances in clinical care, research, and technology in critical care medicine with a focus on the kidney and renal support techniques.
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