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Scientific Publications

SphingoTec's biomarker discovery is based on the highest standard of evidence, with over 100 publications, over 100 clinical studies, and more than 100.000 patients enrolled. Browse our scientific publications to learn more about how our biomarkers can impact patient care. You can use filters to narrow your search results by Year, Biomarker and Indications.

2023 penKid Other

Proenkephalin A 119–159 (penKid) – a novel biomarker and its quantification on the Nexus IB10 POC system for assessing kidney function

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2023 bio-ADM Other

Prognostic Value for Mortality of Plasma Bioactive Adrenomedullin in Patients with Pulmonary Arterial Hypertension: A Sub Analysis of the Biomarker Study in the COHARD-PH Registry

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2023 bio-ADM Other

Plasma bioactive adrenomedullin on intensive care unit admission is associated with acute respiratory distress syndrome: an observational study

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2023 bio-ADM penKid Other

Biomarkers as prognostic predictors and therapeutic guide in critically ill patients: clinical evidence

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2023 penKid Acute Kidney Injury Other

Renal Biomarkers in Cardiovascular Patients with Acute Kidney Injury: A Case Report and Literature Review

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2023 penKid Acute Kidney Injury Other

Assessing GFR with Proenkephalin

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2023 bio-ADM penKid Major Surgery Other

Proenkephalin A and bioactive adrenomedullin are useful for risk prognostication in cardiac surgery

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2023 bio-ADM Major Surgery Other

Bioactive adrenomedullin (bio-ADM) is associated with endothelial dysfunction in infants and children with complex congenital heart disease undergoing open-heart surgery on cardiopulmonary bypass

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2023 penKid Other

Plasma Pro-Enkephalin A and incident cognitive impairment: The reasons for geographic and racial differences in stroke cohort

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2022 bio-ADM Cardiovascular Disease Other

Association of Plasma Bioactive Adrenomedullin Levels with Cardiovascular Risk Factors in BCRA1/2 Mutation Carriers - Zusammenhang zwischen bioaktivem Adrenomedullin-Spiegel und kardiovaskulären Risikofaktoren bei BCRA1/2-Mutationsträgerinnen

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2022 bio-ADM Other

Analytical performance evaluation of bioactive adrenomedullin on point-of-care platform

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2022 penKid pro-ENK Acute Kidney Injury Other

Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function

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2022 bio-ADM Sepsis Other

Can Acute Care Biomarkers change Patient´s Management in Spepsis?

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2022 DPP3 Cardiovascular Disease Sepsis Other

Safety and tolerability of non‑neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS‑2 phase 2a biomarker‑guided trial

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2022 bio-ADM penKid Sepsis Other

30 Days Mortality Prognostic Value of POCT Bio-Adrenomedullin and Proenkephalin in Patients with Sepsis in the Emergency Department

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2023 penKid Other

Proenkephalin A 119-159 predicts early and successful liberation from renal replacement therapy in critically ill patients: a post hoc analysis of the ELAIN trial

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2022 bio-ADM Other

Biologically Active Adrenomedullin (bio-ADM) is of potential value in identifying congestion and selecting patients for neurohormonal blockade in acute dyspnea

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2022 DPP3 Cardiogenic Shock Sepsis Other

The emerging role of dipeptidyl peptidase 3 in pathophysiology

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2022 bio-ADM Sepsis Other

Bioactive adrenomedullin in sepsis patients in the emergency department is associated with mortality, organ failure and admission to intensive care

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2022 penKid Acute Kidney Injury Other

Role of proenkephalin in the diagnosis of severe and subclinical acute kidney injury during the perioperative period of liver transplantation

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2022 bio-ADM Sepsis Other

Can Acute Care Biomarkers Change Patient’s Management in Sepsis?

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2022 penKid Acute Kidney Injury Sepsis Other

Advances in the study of subclinical AKI biomarkers

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2022 pro-NT Other

New Insights in the Control of Fat Homeostasis: The Role of Neurotensin

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2022 penKid Other

Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes

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2022 DPP3 Other

Dipeptidyl peptidase-3 is associated with severity of liver disease and circulatory complications in patients with cirrhosis

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2021 penKid pro-ENK Other

Plasma Pro-Enkephalin A and Ischemic Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort

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2021 bio-ADM Other

Bioactive adrenomedullin a prognostic biomarker in patients with mild to moderate dyspnea at the emergency department: an observational study

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2021 penKid Other

The effect of FGF21 and its genetic variants on food and drug cravings, adipokines and metabolic traits

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2021 penKid Sepsis Other

Plasma proenkephalin A 119-159 on intensive care unit admission is a predictor of organ failure and 30-day mortality

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2021 DPP3 Sepsis Other

Circulating dipeptidyl peptidase 3 on intensive care unit admission is a predictor of organ dysfunction and mortality

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2021 penKid pro-NT Heart Failure Other

Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle‑intervention in germline BRCA1/2 gene mutation carriers

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2021 hGH Other

Circulating levels of growth hormone in postural orthostatic tachycardia syndrome

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2021 Other

Novel insights into peptide amidation and amidating activity in the human circulation

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2021 DPP3 Other

Circulatory dipeptidyl peptidase 3 (cDPP3) is a potential biomarker for early detection of secondary brain injury after aneurysmal subarachnoid hemorrhage

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2021 pro-NT Other

Pro-Neurotensin/Neuromedin N and risk of incident metabolic syndrome and diabetes mellitus in the REGARDS cohort

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2021 bio-ADM DPP3 penKid Other

Plasma proenkephalin A 119 159 and dipeptidyl peptidase 3 on admission after cardiac arrest help predict long-term neurological outcome

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2021 bio-ADM DPP3 Other

Circulating biomarkers to assess cardiovascular function in critically ill

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2021 bio-ADM Other

Levels of bioactive adrenomedullin in plasma and cerebrospinal fluid in relation to delayed cerebral ischemia in patients after aneurysmal subarachnoid hemorrhage: A prospective observational study

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2020 penKid Other

The effects of physical exercise on the assessment of kidney function

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2020 penKid Other

Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age

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2020 pro-ENK Other

High circulating levels of midregional proenkephalin A predict vascular dementia: a population-based prospective study

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2020 pro-NT Other

Pro-Neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease

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2020 pro-NT Other

Pro-neurotensin/neuromedin N and risk of cognitive impairment in a prospective study

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2020 pro-NT Other

Magnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after standardized oral intake of both saturated and unsaturated fat

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2019 penKid Other

One-year prognosis of kidney injury at discharge from the ICU: A multicenter observational study

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2019 bio-ADM Other

Bioactive adrenomedullin, organ support therapies, and survival in the critically ill: Results from the French and European Outcome Registry in ICU study

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2019 DPP3 Other

A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate

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2019 pro-NT Other

Circulating pro-neurotensin in gestational diabetes mellitus

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2019 pro-TA pro-ENK hGH Other

Detection of early breast cancer beyond mammographic screening: a promising biomarker panel

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2019 pro-NT Other

The association between plasma proneurotensin and glucose regulation is modified by country of birth

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2018 penKid Other

Proenkephalin and risk of developing chronic kidney disease: the prevention of renal and vascular end-stage disease study

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2018 penKid Other

Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report

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2018 penKid Other

Analytical performance of an immunoassay to measure proenkephalin

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2018 penKid Other

Proenkephalin for the early detection of acute kidney injury in hospitalized patients with chronic kidney disease

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2018 bio-ADM Other

Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

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2018 DPP3 Other

Novel Methods for the Quantification of Dipeptidyl Peptidase 3 (DPP3) Concentration and Activity in Human Blood Samples

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2018 pro-NT Other

Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy

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2018 pro-NT Other

The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

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2018 pro-NT Cardiovascular Disease Other

Proneurotensin predicts cardiovascular disease in an elderly population

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2018 pro-NT Other

Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity

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2018 pro-NT Other

Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus

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2018 pro-NT Other

Increased plasma proneurotensin Levels identify NAFLD in adults with and without type 2 diabetes

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2017 penKid Other

High Level of fasting plasma proenkephalin-A predicts deterioration of kidney function and incidence of CKD

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2017 penKid Other

Proenkephalin (PENK) as a Novel Biomarker for Kidney Function

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2017 bio-ADM Other

Sandwich immunoassay for bioactive plasma adrenomedullin

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2017 pro-NT Other

No relation between biomarkers at age 47–49 and aortic diameter after 14–19 years of follow-up –a population-based study

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2017 hGH Other

Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

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2016 pro-NT Other

Role of proneurotensin as marker of paediatric coeliac disease

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2016 pro-NT Other

An obligatory role for neurotensin in high-fat-diet induced obesity

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2015 pro-ENK Other

Serum Proenkephalin A levels and mortality after long-term follow-up in patients with type 2 diabetes mellitus (ZODIAC-32)

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2015 pro-TA pro-ENK pro-NT Other

Basal plasma levels of copeptin are elevated in inactive inflammatory bowel disease after bowel resection

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2015 pro-ENK Other

Stable peptide of the endogenous opioid enkephalin precursor and breast cancer risk

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2014 pro-NT Other

Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer

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2012 pro-NT Cardiovascular Disease Other

Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality

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2012 pro-TA Other

Elevated plasma levels of neuropeptide proenkephalin A predict mortality and functional outcome in ischemic stroke

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2010 pro-TA Other

Midregional proenkephalin A and N-terminal protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation

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2008 pro-TA Other

Detection of stable N-terminal protachykinin A immunoreactivity in human plasma and cerebrospinal fluid

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2006 pro-NT Other

Proneurotensin 1–117, a stable neurotensin precursor fragment identified in human circulation

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