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Scientific Publications

SphingoTec's biomarker discovery is based on the highest standard of evidence, with over 100 publications, over 100 clinical studies, and more than 100.000 patients enrolled. Browse our scientific publications to learn more about how our biomarkers can impact patient care. You can use filters to narrow your search results by Year, Biomarker and Indications.

2023 penKid Other

Proenkephalin A 119–159 (penKid) – a novel biomarker and its quantification on the Nexus IB10 POC system for assessing kidney function

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2023 bio-ADM penKid Major Surgery Other

Proenkephalin A and bioactive adrenomedullin are useful for risk prognostication in cardiac surgery

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2022 penKid pro-ENK Acute Kidney Injury

Letter to the editor: "Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function"

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2022 penKid pro-ENK Acute Kidney Injury Other

Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function

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2022 bio-ADM penKid Sepsis Other

30 Days Mortality Prognostic Value of POCT Bio-Adrenomedullin and Proenkephalin in Patients with Sepsis in the Emergency Department

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2022 penKid Acute Kidney Injury Other

Role of proenkephalin in the diagnosis of severe and subclinical acute kidney injury during the perioperative period of liver transplantation

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2022 penKid Acute Kidney Injury

Advances in the study of subclinical AKI biomarkers

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2022 penKid Acute Kidney Injury Sepsis Other

Advances in the study of subclinical AKI biomarkers

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2022 penKid Other

Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes

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2021 penKid pro-ENK Other

Plasma Pro-Enkephalin A and Ischemic Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort

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2021 penKid pro-TA Heart Failure

Neprilysin inhibition does not alter dynamic of proenkephalin-A 119-159 and pro-substance P in heart failure

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2021 penKid Heart Failure

Proenkephalin and the risk of new-onset heart failure: data from PREVEND

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2021 penKid Other

The effect of FGF21 and its genetic variants on food and drug cravings, adipokines and metabolic traits

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2021 penKid Sepsis Other

Plasma proenkephalin A 119-159 on intensive care unit admission is a predictor of organ failure and 30-day mortality

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2021 penKid pro-NT Heart Failure Other

Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle‑intervention in germline BRCA1/2 gene mutation carriers

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2021 penKid Acute Kidney Injury

Acute kidney injury in the critically ill: an updated review on pathophysiology and management

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2021 penKid Acute Kidney Injury Cardiogenic Shock

Predictive value of plasma proenkephalin and neutrophil gelatinase‑associated lipocalin in acute kidney injury and mortality in cardiogenic shock

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2021 penKid Acute Kidney Injury

Potential long-term health problems associated with ultra-endurance running: a narrative review

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2021 bio-ADM DPP3 penKid Other

Plasma proenkephalin A 119 159 and dipeptidyl peptidase 3 on admission after cardiac arrest help predict long-term neurological outcome

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2020 penKid Acute Kidney Injury Major Surgery

Proenkephalin A 119-159 may predict post-operative acute kidney injury and in hospital mortality following open or endovascular thoraco-abdominal aortic repair

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2020 penKid Acute Kidney Injury Sepsis

Incidence and outcome of sub-clinical acute kidney injury using penKid in critically ill patients

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2020 penKid Burns

PenKid measurement at admission is associated with outcome in severely ill burn patients

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2020 penKid Other

The effects of physical exercise on the assessment of kidney function

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2020 penKid Sepsis

Proenkephalin compared to conventional methods to assess kidney function in critically ill sepsis patients

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2020 penKid Acute Kidney Injury

Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference - a consensus statement

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2020 penKid Acute Kidney Injury

Proenkephalin: a new biomarker for glomerular filtration rate and acute kidney injury

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2020 penKid Sepsis

Proenkephalin predicts organ failure, renal replacement therapy, and mortality in patients with sepsis

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2020 penKid Other

Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age

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2020 bio-ADM penKid Acute Kidney Injury Sepsis

The value of plasma pro-enkephalin and adrenomedullin for the prediction of sepsis-associated acute kidney injury in critically ill patients

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2019 penKid Sepsis

Proenkephalin a 119–159 (penKid) – a novel biomarker for acute kidney injury in sepsis: an observational study

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2019 penKid Other

One-year prognosis of kidney injury at discharge from the ICU: A multicenter observational study

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2019 penKid Heart Failure

Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study

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2019 penKid Heart Failure

Proenkephalin, an opioid system surrogate, as a novel comprehensive renal marker in heart failure

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2018 penKid Heart Failure

Proenkephalin in heart failure

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2018 penKid Other

Proenkephalin and risk of developing chronic kidney disease: the prevention of renal and vascular end-stage disease study

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2018 penKid Sepsis

Proenkephalin A 119-159 (Penkid) is an early biomarker of septic acute kidney injury: the kidney in sepsis and septic shock (Kid-SSS) study

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2018 penKid Other

Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report

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2018 penKid Other

Analytical performance of an immunoassay to measure proenkephalin

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2018 penKid Sepsis

Circulating proenkephalin, acute kidney injury, and its improvement in patients with severe sepsis or shock

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2018 penKid Other

Proenkephalin for the early detection of acute kidney injury in hospitalized patients with chronic kidney disease

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2017 penKid Heart Failure

Worsening renal function in heart failure: it takes 2 to tangle

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2017 penKid Other

High Level of fasting plasma proenkephalin-A predicts deterioration of kidney function and incidence of CKD

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2017 penKid Heart Failure

Proenkephalin, renal dysfunction, and prognosis in patients with acute heart failure: A GREAT network study

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2017 penKid Major Surgery

Elevated soluble urokinase plasminogen activator receptor and proenkephalin serum levels predict the development of acute kidney injury after cardiac surgery

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2017 penKid Heart Failure

Clinical correlates and prognostic value of proenkephalin in acute and chronic heart failure

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2017 penKid Sepsis

Proenkephalin, neutrophil gelatinase-associated lipocalin, and estimated glomerular filtration rates in patients with sepsis

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2017 penKid Renal Transplantation

Plasma proenkephalin and poor long-term outcome in renal transplant recipients

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2017 penKid Other

Proenkephalin (PENK) as a Novel Biomarker for Kidney Function

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2016 penKid Heart Failure

Prognostic usefulness of proenkephalin in stable ambulatory patients with heart failure

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2015 penKid Cardiogenic Shock

Proenkephalin predicts acute kidney injury in cardiac surgery patients

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2014 penKid Acute myocardial infarction

Proenkephalin and prognosis after acute myocardial infarction

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