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Scientific Publications

SphingoTec's biomarker discovery is based on the highest standard of evidence, with over 100 publications, over 100 clinical studies, and more than 100.000 patients enrolled. Browse our scientific publications to learn more about how our biomarkers can impact patient care. You can use filters to narrow your search results by Year, Biomarker and Indications.

2020 DPP3 Cardiogenic Shock

Circulating plasma dipeptidyl dipeptidase 3 and the prognosis of cardiogenic shock

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2020 bio-ADM DPP3 Sepsis

Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3

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2020 penKid Sepsis

Incidence and outcome of sub-clinical acute kidney injury using penKid in critically ill patients

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2020 penKid Sepsis

Proenkephalin compared to conventional methods to assess kidney function in critically ill sepsis patients

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2020 penKid Other

Proenkephalin: a new biomarker for glomerular filtration rate and acute kidney injury

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2020 bio-ADM Sepsis

Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness

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2020 bio-ADM Sepsis

Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

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2019 bio-ADM Heart Failure

Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure

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2019 bio-ADM Sepsis

Circulating biologically active adrenomedullin predicts organ failure and mortality in sepsis

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2018 penKid Sepsis

Circulating proenkephalin, acute kidney injury, and its improvement in patients with severe sepsis or shock

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2018 bio-ADM Sepsis

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

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2017 penKid Heart Failure

Worsening renal function in heart failure: it takes 2 to tangle

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2017 penKid Other

Proenkephalin (PENK) as a Novel Biomarker for Kidney Function

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2017 bio-ADM Sepsis

Circulating biologically active adrenomedullin (bio-ADM) predicts hemodynamic support requirement and mortality during sepsis

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2021 bio-ADM DPP3 Heart Failure

Biomarkers in Acute Heart Failure: Diagnosis, Prognosis, and Treatment

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2020 penKid Major Surgery

Proenkephalin A 119-159 may predict post-operative acute kidney injury and in hospital mortality following open or endovascular thoraco-abdominal aortic repair

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2020 penKid Burns

PenKid measurement at admission is associated with outcome in severely ill burn patients

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2020 penKid Other

The effects of physical exercise on the assessment of kidney function

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2020 penKid Acute Kidney Injury

Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference - a consensus statement

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2020 penKid Sepsis

Proenkephalin predicts organ failure, renal replacement therapy, and mortality in patients with sepsis

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2020 penKid Other

Proenkephalin as a new biomarker for pediatric acute kidney injury - reference values and performance in children under one year of age

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2020 bio-ADM penKid Sepsis

The value of plasma pro-enkephalin and adrenomedullin for the prediction of sepsis-associated acute kidney injury in critically ill patients

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2020 bio-ADM Heart Failure

Increased concentrations of bioactive adrenomedullin subsequently to ARNi treatment in chronic systolic heart failure

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2020 bio-ADM Major Surgery

Postoperatively increased bioactive adrenomedullin is related to adverse outcome after complex aortic surgery

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2020 bio-ADM Heart Failure

Bioactive adrenomedullin in plasma is associated to biventricular filling pressures in patients with advanced heart failure

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2020 bio-ADM Heart Failure

Congestion in heart failure: a contemporary look at physiology, diagnosis and treatment

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2020 DPP3 Cardiogenic Shock

Alteration of the renin-angiotensin-aldosterone system in shock: Role of the dipeptidyl peptidase 3

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2020 DPP3 Cardiogenic Shock

An outlook on biomarkers in cardiogenic shock

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2020 DPP3 Major Surgery

In-hospital mortality and organ failure after open and endovascular thoraco-abdominal aortic surgery can be predicted by increased levels of circulating dipeptidyl peptidase 3

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2020 DPP3 COVID-19

Angiotensin II treatment in COVID-19 patients: more risk than benefit? A singlecenter experience

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2020 DPP3 Burns

Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients

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2020 pro-ENK Other

High circulating levels of midregional proenkephalin A predict vascular dementia: a population-based prospective study

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2020 pro-NT Other

Pro-Neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease

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2020 pro-NT Other

Pro-neurotensin/neuromedin N and risk of cognitive impairment in a prospective study

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2020 pro-NT Other

Magnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after standardized oral intake of both saturated and unsaturated fat

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2008 pro-TA Other

Detection of stable N-terminal protachykinin A immunoreactivity in human plasma and cerebrospinal fluid

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2010 pro-TA Other

Midregional proenkephalin A and N-terminal protachykinin A are decreased in the cerebrospinal fluid of patients with dementia disorders and acute neuroinflammation

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2014 pro-TA Acute myocardial infarction

Pro-substance P for evaluation of risk in acute myocardial infarction

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2012 pro-TA Other

Elevated plasma levels of neuropeptide proenkephalin A predict mortality and functional outcome in ischemic stroke

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2019 penKid Sepsis

Proenkephalin a 119–159 (penKid) – a novel biomarker for acute kidney injury in sepsis: an observational study

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2019 penKid Other

One-year prognosis of kidney injury at discharge from the ICU: A multicenter observational study

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2019 penKid Heart Failure

Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study

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2019 penKid Heart Failure

Proenkephalin, an opioid system surrogate, as a novel comprehensive renal marker in heart failure

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2019 bio-ADM Heart Failure

Adrenomedullin in heart failure: pathophysiology and therapeutic application

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2019 bio-ADM Heart Failure

Adrenomedullin, a circulating biomarker of congestion: in search of evidence

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2019 bio-ADM Heart Failure

Clinical value of pre-discharge bio-adrenomedullin as a marker of residual congestion and high risk of heart failure hospital readmission

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2019 bio-ADM Heart Failure

Bioactive adrenomedullin, proenkephalin A and clinical outcomes in an acute heart failure setting

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2019 bio-ADM Other

Bioactive adrenomedullin, organ support therapies, and survival in the critically ill: Results from the French and European Outcome Registry in ICU study

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2019 bio-ADM Heart Failure

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

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2019 DPP3 Cardiogenic Shock

Circulating dipeptidyl peptidase 3 and alteration in haemodynamics in cardiogenic shock: results from the OptimaCC trial

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2019 DPP3 Cardiogenic Shock

Dipeptidyl peptidase 3, a biomarker in cardiogenic shock and hopefully much more

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2019 DPP3 Other

A novel and highly efficient purification procedure for native human dipeptidyl peptidase 3 from human blood cell lysate

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2019 DPP3 Heart Failure Cardiogenic Shock

Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics

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2019 pro-NT Other

Circulating pro-neurotensin in gestational diabetes mellitus

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2019 Sel-P Cardiovascular Disease

Selenoprotein-P deficiency predicts cardiovascular disease and death

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2019 pro-TA pro-ENK hGH Other

Detection of early breast cancer beyond mammographic screening: a promising biomarker panel

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2019 pro-NT Other

The association between plasma proneurotensin and glucose regulation is modified by country of birth

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2019 Sel-P Heart Failure

Selenoprotein P deficiency and risk of mortality and rehospitalization in acute heart failure

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2018 penKid Heart Failure

Proenkephalin in heart failure

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2018 penKid Other

Proenkephalin and risk of developing chronic kidney disease: the prevention of renal and vascular end-stage disease study

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2018 penKid Sepsis

Proenkephalin A 119-159 (Penkid) is an early biomarker of septic acute kidney injury: the kidney in sepsis and septic shock (Kid-SSS) study

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2018 penKid Other

Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report

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2018 penKid Other

Analytical performance of an immunoassay to measure proenkephalin

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2018 penKid Other

Proenkephalin for the early detection of acute kidney injury in hospitalized patients with chronic kidney disease

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2018 bio-ADM Heart Failure

Bio-adrenomedullin as a potential quick, reliable, and objective marker of congestion in heart failure

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2018 bio-ADM Sepsis

Vascular effects of adrenomedullin and the anti-adrenomedullin antibody Adrecizumab in sepsis

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2018 bio-ADM Sepsis

Adrenomedullin and adrenomedullin-targeted therapy as treatment strategies relevant for sepsis

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2018 bio-ADM Other

Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

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2018 DPP3 Other

Novel Methods for the Quantification of Dipeptidyl Peptidase 3 (DPP3) Concentration and Activity in Human Blood Samples

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2018 pro-NT Other

Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy

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2018 pro-NT Cardiovascular Disease

Usefulness of proneurotensin to predict cardiovascular and all-cause mortality in a United States population (from the reasons for geographic and racial differences in stroke study)

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2018 pro-NT Other

The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

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2018 pro-NT Cardiovascular Disease Other

Proneurotensin predicts cardiovascular disease in an elderly population

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2018 pro-NT Other

Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity

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2018 pro-NT Other

Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus

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2018 pro-NT Other

Increased plasma proneurotensin Levels identify NAFLD in adults with and without type 2 diabetes

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2017 penKid Other

High Level of fasting plasma proenkephalin-A predicts deterioration of kidney function and incidence of CKD

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2017 penKid Heart Failure

Proenkephalin, renal dysfunction, and prognosis in patients with acute heart failure: A GREAT network study

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2017 penKid Major Surgery

Elevated soluble urokinase plasminogen activator receptor and proenkephalin serum levels predict the development of acute kidney injury after cardiac surgery

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2017 penKid Heart Failure

Clinical correlates and prognostic value of proenkephalin in acute and chronic heart failure

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2017 penKid Sepsis

Proenkephalin, neutrophil gelatinase-associated lipocalin, and estimated glomerular filtration rates in patients with sepsis

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2017 penKid Renal Transplantation

Plasma proenkephalin and poor long-term outcome in renal transplant recipients

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2017 bio-ADM Acute myocardial infarction

Prognostic value of human mature adrenomedullin in patients with acute myocardial infarction

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2017 bio-ADM Other

Sandwich immunoassay for bioactive plasma adrenomedullin

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2017 bio-ADM Cardiogenic Shock

Adrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock

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2017 pro-NT Other

No relation between biomarkers at age 47–49 and aortic diameter after 14–19 years of follow-up –a population-based study

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2017 hGH Other

Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment

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2016 penKid Heart Failure

Prognostic usefulness of proenkephalin in stable ambulatory patients with heart failure

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2016 bio-ADM Sepsis

Plasma adrenomedullin in critically ill patients with sepsis after major surgery: a pilot study

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2016 bio-ADM Heart Failure

Plasma bioactive adrenomedullin as a prognostic biomarker in acute heart failure

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2016 pro-NT Other

Role of proneurotensin as marker of paediatric coeliac disease

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2016 pro-NT Other

An obligatory role for neurotensin in high-fat-diet induced obesity

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2016 pro-NT Cardiovascular Disease

Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community The Framingham Heart Study

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2015 penKid Cardiogenic Shock

Proenkephalin predicts acute kidney injury in cardiac surgery patients

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2015 pro-ENK Sepsis

Diagnostic and short-term prognostic utility of plasma proenkephalin (pro-ENK) for acute kidney injury in patients admitted with sepsis in the emergency department

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2015 pro-ENK Other

Serum Proenkephalin A levels and mortality after long-term follow-up in patients with type 2 diabetes mellitus (ZODIAC-32)

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2015 pro-TA pro-ENK pro-NT Other

Basal plasma levels of copeptin are elevated in inactive inflammatory bowel disease after bowel resection

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2015 pro-ENK Other

Stable peptide of the endogenous opioid enkephalin precursor and breast cancer risk

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2015 hGH Acute myocardial infarction

Growth hormone for risk stratification and effects of therapy in acute myocardial infarction

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2015 hGH Heart Failure

Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure

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2014 penKid Acute myocardial infarction

Proenkephalin and prognosis after acute myocardial infarction

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2014 bio-ADM Sepsis

Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis

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2014 hGH Cardiovascular Disease

Fasting levels of high-sensitivity growth hormone predict cardiovascular morbidity and mortality: the Malmö Diet and Cancer study

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2014 pro-NT Other

Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer

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2012 pro-NT Cardiovascular Disease Other

Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality

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2006 pro-NT Other

Proneurotensin 1–117, a stable neurotensin precursor fragment identified in human circulation

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