Acute Care

Innovative acute care biomarkers


SphingoTec develops and markets innovative in vitro diagnostic (IVD) tests for novel and proprietary biomarkers for the diagnosis, prediction and monitoring of acute medical conditions, such as sepsis, acute heart failure, circulatory shock, and acute kidney injury in order to support patient management and provide guidance for treatment strategies. The IVD tests for SphingoTec’s proprietary biomarkers are made available as sphingotest® microtiterplate tests as well as point-of-care tests on the Nexus IB10 immunoassay platform by our subsidiary Nexus Dx Inc.


bio-ADM®- endothelial function biomarker

Bioactive Adrenomedullin (bio-ADM®), is a dynamic biomarker for the real time assessment of endothelial function. Loss of endothelial function is causing the formation of edema, shock and subsequent organ failure in critically ill patients.



penKid® - kidney function biomarker

Proenkephalin (penKid®), is a dynamic biomarker for the real time assessment of kidney function. penKid® is a blood-based alternative for detecting true glomerular filtration rate (true GFR) that is applicable in routine laboratory testing independent from inflammation and comorbidities.

kidney proenkephalin


DPP3 – cardiac depression factor

Dipeptidyl Peptidase 3 (DPP3), is a dynamic biomarker for assessing DPP3 release – one major cause of cardiac depression. The enzyme is at the core of a recently discovered disease mechanism leading to vasopressor-resistant shock and short-term organ dysfunction.

DPP3 cardiac depressant