Biomarkers for critical conditions
The biomarkers developed by SphingoTec address critical conditions that are a global healthcare burden. Worldwide about 49 million people suffer from sepsis (1) and 13 million from acute kidney injury (2). They are life-threatening diseases with high hospitalization costs. The innovative biomarkers aim at providing actionable information for improved patient management.
Kidney function biomarker
Proenkephalin A 119-159 (penKid*)
PenKid, is a dynamic biomarker for the real-time assessment of kidney function. penKid is a blood-based alternative reflecting true GFR that is applicable in routine laboratory testing independent of inflammation and common comorbidities.
Endothelial function biomarker
Bioactive Adrenomedullin 1-52 (bio-ADM*)
Bio-ADM is a dynamic biomarker for the real-time assessment of endothelial function. Loss of endothelial function is causing the formation of edema, shock, and subsequent organ failure in critically ill patients.
Cardiac depression factor
Dipeptidyl Peptidase 3 (DPP3*)
DPP3 is a dynamic biomarker for assessing DPP3 which is, when released into the bloodstream, one major cause of cardiac depression. The enzyme is at the core of a recently discovered disease mechanism leading to hemodynamic instability and short-term organ dysfunction.
*Disclaimer
Sphingotest® penKid®, sphingotest® bio-ADM®, sphingotest® DPP3 are offered for in vitro diagnostics. “penKid”, “bio-ADM” and “DPP3” represent the analytes Proenkephalin A 119-159, bioactive Adrenomedullin 1-52, and Dipeptidyl Peptidase 3, respectively.
Reference Literature
(1) Rudd et al. (2020), Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study, The Lancet.
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(2) Mehta et al. (2015), International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet.
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